Spatially Restricted Increase in Polysialic Acid Enhances Corticospinal Axon Branching Related to Target Recognition and Innervation
نویسندگان
چکیده
منابع مشابه
Spatially restricted increase in polysialic acid enhances corticospinal axon branching related to target recognition and innervation.
The polysialic acid (PSA) modification of the neural cell adhesion molecule (NCAM) has been shown to alter the responses of developing axons to their environment. We have studied the potential role of PSA in regulating the innervation of the spinal cord by corticospinal axons, which occurs by a delayed formation of collateral branches from the parent axons. Developmental changes in the distribu...
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Corticospinal axons innervate their midbrain, hindbrain, and spinal targets by extending collateral branches interstitially along their length. To establish that the axon shaft rather than the axonal growth cone is responsible for target recognition in this system, and to characterize the dynamics of interstitial branch formation, we have studied this process in an in vivo-like setting using sl...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1996
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.16-17-05488.1996